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KMID : 0607519960040010044
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Korean Journal of Psychosomatic Medicine
1996 Volume.4 No. 1 p.44 ~ p.53
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Behavioral Response and immune Alterations by Electric Footshock in Mice
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Kim Jung-Bum
Park Won-Kyun
Song Dae-Kyu
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Abstract
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The present experiment was designed to investigate the effects of behavioral, response to immune function in response to electric footshock in mice. Mice were subjected to electric footshock for 3 days(two sessions a day, 11 times of shock for about 31 minutes a session). The humoral immune response was measured using mice immunized with rat RBC. The cell-mediated immune responses were evaluated by contact hypersensitivity to 2, 4-dinitrofluorobenzene(DNFB) and by phytohemagglutin(PHA)-stimulated splenocytes proliferation assay. In stressed group, electric footshock suppressed significantly anti-rat RBC antibody production(p<0.05), but enhanced significantly relative to in contact hypersenstivry (P<.01) and T-cell proliferation response(P<.05) by PHA stimulation elative to control group. T-cell proliferation response by PHA stimulation was significantly correlated to the movement than the sensitivity and coping behavior in the mouse, in response to the electric footshock. These data supper the importance of behavioral response in stress-induced changes of immune functions.
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KEYWORD
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Electric footshock, Behavioral response, Immune function
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